Histogenesis of Coexistend Cylindroma and Trichoepithelioma
DOI:
https://doi.org/10.5644/Radovi.144Abstract
Histological and histochemical investigations of biopsies of lesions from a 17 year old patient without hereditary anamnesis having multiple lesions on the face, scalp, back, supraclavicular and brachial region clinically resembling trichoepithelioma could show primarily typical formations of dermal cylindroma and trichoepithelioma but also other immature types of epidermal structures which were occurring not only separate in different lesions but side by side in the same lesion with varying degrees of atypicality and maturity. This occurrence might be explained histogenetically on a similar way as Lever is trying to explain the occasionally finding of trichoepithelioma and cylindroma in the same patient namely by assuming that there is a common genesis for both lesions from pluripotential germ cells.
The concept of pluripotential and equipotentiality of the matrix epidermal cells and its appendages may be accepted as the most plausible explanation for the histogenesis of cylindroma, trichoepithelioma and other adnexal tumours, although the circumstances under which this inherited genetically determined potency may became manifested in adult skin is not yet understood and defined.
Analogous to basal cell epithelioma as pointed out by Pinkus a. all, the epithelial proliferation goes hand in hand also in benign adnexal tumours with the new formation of connective tissue stroma. The mesenchyme tissue could be supposed to be responsible in exerting the simulative effect and the characteristic differentiation on the adult epithelium in hereditary determined individual which transformation is mostly not fully developed.
References
Bandmann H. J., D. Hamburger und N. Rom i ti: Bericht zur Brooke-Spieglerschen Phakomatose. Hautarzt 16, 450—453, 1965.
Barka T. and P. J. Anderson: Histochemistry, New York, Hoeber Med. Div. Harper and Row, 1963.
Braun — Falco O.: Uber die Fahigkeit der menschlischen Haut zur Polysaccharidsynthese. Ein Beitrag zur Histotopochimie der Phosphorylase. Arch. Klin. exp. Derm. 202, 163—170, 1956.
Braun — Falco O.: Die Histochemic der Haut. Im: Dermatologie und Venereologie (H. A. Gottron u. W. Schonfeld Hrsg.) Bd I/I 366—472, Stuttgart, G. Thieme, 1961.
Crain R. C. and E. B. Helwig: Dermal cylindroma (dermal ecerine cylinderma). Amer. J. elin. Path. 35, 504—515, 1961.
Feyrter F., H. Gottron u. W. Nikolowski: tlber das Cylindrom der Haut. Arch. klin. exp. Derm. 214, 54—104, 1961.
Fusaro R. M. andR. W. Goltz: Histochemically demonstrable carbohydrates of appendageal tumors of the skin. II. Benign apocrine gland tumors. J. Invest. Derm. 38, 137—142, 1962.
Ellis R. A. and W. Montagna: Histology and cytochemistry of human skin. XV. Sites of phosphorylase and amylo 1,6 glucosidase activity. J. Histochem. Cytochem. 6,201—207, 1958.
Goldstein J., Graha m J. H., Urbacj F. and Munger B. L.: Dermal eccrine cylindroma — a histochemical, electronmicroscopic and therapeutic (X ray) study. Arch. Derm. 88, 880—894, 1963.
Gomori G.: Microscopic Histochemistry. Principle and Practice. The University Chicago Press, 1962.
Graul E. H.: Spieglersche Zylindrome und Epitheliome adenoides cysticum. Derm. Wschr. 128, 949, 1953.
Greitner A.: Basaliome von Typus Spiegler. Arch. klin. exp. Derm. 187, 224—252, 1949.
Hashimoto K. and W. F. Lever: Appendage tumors of the skin. Charles Thomas publisher, Springfield, 1968.
Holubar K. ans K. Wolff: Zur Histogenese des Cylindroms. Arch. Klin. exp. Derm. 229, 215—216, 1967.
Kleine-Natrop, H. E.: Gleichzeitige Generalisation gutartiger Basaliome der beiden Typen Spiegler und Brooke. Arch. klin. exp. Derm. 209, 45—55, 1959.
Knoth W. and G. Ehlers: Uber das Epithelioma adenoides cysticum als Phakomatose Brooke-Spiegler. Zugleich in Beitrag zu den anlagebedingten und ervvorbcnen Basaliomen. Hautartz II, 535—545, 1960.
Kligman A. M. and Pinkus H.: The Histogenesis of Nevoid Tumors of the Skin. AMA Arch. Derm. 81, 922, 1960.
Lever W. F.: Pathogenesis of benign tumors of cutaneous appendages and of basal cell epithelioma: I. Benign tumors of the cutaneous appendages. Arch. Derm. Syph. (Chic.) 57, 679—708, 1948.
W. F. Lever: Histopatology of the skin. Philadelphia, Lippincott 1961.
Luce J. K. and Bean W. B.: Turban Tumors. Arch. Inter. Med. 106, 204—244, 1960.
Montagna W.: Histology and cytology of human skin. XIX. The development and fate of the axillary organ. J. Invest. Derm. 33, 151—162, 1959.
Montagna W.: The Structurc and Function of Skin. Ed. 2. New York, Academic Press, 1962.
Mungcr B. L., J. H. Graham and E. B. Helwig: Ultrastructure and histochemical characteritics of dermal ecerinc cylindroma (Turban tumor). J. Invest. Dcr., 39, 577—595, 1963.
Nodl F.: Zur Histogenese der dermalen ekkrinen Cylindrome. Arch. Klin. Exp. Derm. 22, 171—191, 1965.
Pinkus H.: Epithelial and Fi broepithelial Tumors. Arch. Derm. 91, 24—38, 1965.
Pinkus H.: Pathogenesis of Premalignant and Malignant Conditions of the Skin. Symposium on Skin, Indianopolis, 1957.
Pinkus H.: Biology of hair grovvth. In: Montagna W. and R. A. Ellis, New York, Acad. Press, 1959.
Pearce A. G. E.: Histochcmistry. Theorctical and Applied. 2nd ed. Little Brovvn, Boston, 1961.
Spier H. W. u. P. v. Caneghem : Zur Histochemie dcr Verhornung Arch. Klin. exp. Derm. 206, 344—363, 1957.
Takeuschi T.: Histochemical demonstration of branehing enzyme (amylo 1,4—1,6 transglucosidase) in animal tissues. J. Histoch. Cytochem. 6, 208—216, 1958.
Winkelmann E. K. and S. H. Muller : Sweat gland tumor — histochemical studies. Dermatologica 89, 827, 1964.
Urbach F., J. H. Graham, J. Goldstein and B. L. Munger: Dermal eccerine cylindroma. A histochemical, electronmicroscopic and therapeutic (X ray) study Arch. Derm. 88, 880—894, 1963.
Wolff K. und K. Holubar: Zur Enzymohistochemie des Basalioms. Arch. klin. cxp. Derm. 223, 483—500, 1965.
Yasuda K., M. Furusawa and N. Ogata: Histochemical investigation on the phosphorylase in the sweat glands of axilla. Okajimas Folia anat. Jap. 31, 161—169, 1958.
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