Function of Histamine in the Skin
DOI:
https://doi.org/10.5644/Radovi.18Abstract
1) The function of histamine in the skin and its role in the genesis of allergic eccema, tuberculin reaction, inflammation and pain sensation was studied in guines pigs, the most sensitive animals to histamin (H), and in rats which are very resistant to H. The enumerated manifestations were investigated in normal skins and in skins depleted of H by the use of the most potent histamine liberator 48/80.
2) The allergic eccema, provoked in guinea pigs by 2,4-dinitrohlor-benzene is more pronounced in the skin with more H. Therefore, it is more pronounced in the skin behind the auricles as in the skin of the hip, and it does not appear if the skin is depleted of H.
3) The inflammatory reaction was studied on "granuloma pouch" of the rat and it is less pronounced in a rat whose skin was depleted of H. In the inflammated tissue the necroses are less and the proliferations more conspicuous as in the Controls. The same effect was obtained with one water-soluble guiazulene which fixed H in the tissues and prevented its action. Therefore, it is concluded that it is irrelevant for the outcome of inflammation if H is a priori missing from the skin. or if H is prevented to act. For the assanation of an inflammatory focus it is irrelevant if there is H or not. Tuberculine reaction is independent of H concentration in the skin,
4) The pain conduction was studied in rats, guinea pigs and humans. The guinea pigs and the humans have a more intense pain sensation from thermal radiations when the concentration of H in the skin is greater. In guinea pigs the skin on the head and on the hip was investigated, and in humans the skin in the neck (below ears) and from the fingertips. The depletion of H in the skin of these two regions of guinea pigs by use of 48/80 resulted in a diminution of pain sensation, what is consistent with the findings of Feldberg and Miles. Present investigation proved that the same holds for the investigated skin regions in humans. In rats the pain sense in the skin of the back and of paws remained without change notwithstanding the fact that in the paws there is more H. The depletion of H from the skin of rats does not diminish the pain sensation. That is accounted for by the absence of H receptor in the rat skin, namely of diaminooxidase.
5) It is discused the significance of H for the phenomena which were, investigated, aspecially for the inflammation, and the question is raised if H is beneficial or noxious for the inflammatory process.
References
Stern P.: Arch. cxper. Path. u. Pharmakol. 199,251, (1942).
Halpern. B. N. Arch. int. Pharmacodyn. 68,339 (1942).
Schayer R.: J. Biol. Chcm. 196,468 (1952). 203,787 (1953).
Mclntosh F.; Patton W.: J. Physiol. 109,190 (1949).
Stern P., Košak R.: Acta med. jugoslav. 5,147 (1951).
Ivy A.: Physiol. Rev. 10,282, (1930).
Haas H.: Histamin und Antihistamine. Ed. Cantor, Aulcndorf 1951.
Hausler H. i Sterz H.: J. Mount Sinai Hosp. 19,121 (1952).
Speckmann K., Specht G.: Dtsch. Z. f. Nervenhcilkunde 170,122 (1953).
Paton W.: Int. Arch. Allergy 6,203 (1955).
Hardvvick D.: J. Physiol. 124,157 (1954).
Wilson C.: J. Physiol. 125,534 (1954).
Guggenheim M.: Die biogenen Amine, S. Karger Verlag, Basel-New York, 1951.
Doer R.: Handbuch der normalen und pathologischen Physiologie, Bd. 13, 1929.
Dale H.: Proc. Roy. Soc. London 91 B, 126, (1920).
Lenčc P., Marijan N., Prcdojević M., Stern P.: Acta med. jug. 3,245, (1949).
Ivančević L, Stern P.,: Arch. int. pharmacodyn. 78,225, (1949).
Stern P.: Medicinski arhiv 5,1, (1951).
Bucher K.: Helv. physiol. acta 6,114, (1948).
Pellerat J.: Thesis Lyon 1946.
Fabyni M., Szebehelyi J. Schvveiz. med. Wschr. 299, (1949).
Paton W.: Brit. J. Pharmacol. 6,499, (1951).
Feldberg W„ Talesnik J.: J. Physiol. 120,550, (1953).
Feldberg W.: J. of Pharmacy and Pharmacology 6,281, (1954).
Feldberg W., Miles A.: J. Physiol. 120,205, (1953).
Micscher G.: Schvveiz. med. Waschr. 360, (1941).
Stern P.: Arch. int. pharmacodyn. 105, 270 (1956)
Nilzen A.: Acta dermatovener, 27, Suppl. 17, (1947).
Stern P.: Neobjavljeni rezultati.
Misirlija A., Huković S., Stern P.: Tuberkuloza. U štampi.
Bucher. J, Bucher K.: Int. Arch. Allergy 3,58, (1952).
Bacq Z. M.: Privatno saopćenje.
Selye H., Horava A.: Second annual Report of Stress, Acta Ine. Publ. Montreal 1952.
Stern P., Nikulin A., Misirlija A., Ciglar M.: Arch. exper. Path. u. Pharmakol. 227, 552 (1956)
Stern P.: Neobjavljeni rezultati.
Janczo M.: Nature London 160,228, (1947).
Stern P., Nikulin A.: Neobjavljeni rezultati.
Stern P.: Erster internationaler Allergiekongress Z rich 524, S. Karger Verlag Basel-Nevv York 1952.
Stern P.: Medicinski pregled. 91, (1956)
Stern P. Milin R.: Arzneimittelforschg. 6445 (1956)
Ungar G.: J. Physiol. Path. Gen. 34,77, (1936).
Rosenthal S. R., Minard D; Amer. J. Physiol. 126, 616P. (1939).
Rosenthal S. R., Sonnenschein R. R.: Amer. J. Physiol. 155,186 ,(1948).
Rosenthal S. R.: J. Appl. Phvsiol. 2,348, (1949).
Bornemisza GY., Csalay L., Horvath G.,Ludany G.: Acta m?d. hung. 8,187,(1955).
Stern P., Huković S.: Pfl gers Arch.„Arch .int. pharmacodejn 108,273 (1956)
Brocklchurst W. E., Humphrey J; H., Perry W. L.: J. of Physiol. 129,205, (1955).
Nachmanson D.: J. Cell. Comp. Physiol. 39, Suppl. 2, (1951).
Stern P.: Neobjavljeni rezultati.
Valetta G., Cohen Y.: C. R. Soc. Biol. 146,714, (1952).
Jacob J., Ambrus J., Ambrus C.: Ann. Inrt. Pasteur 81,281, (1951).
Stern P., Huković S., Fukarek V.: Neobjavljeni rezultati.
Parrot J. L., Reuse J.: de Phvsiolgie. 46,99, (1954)
Downloads
Published
Issue
Section
License
Copyright (c) 2026 Pavao Štern
This work is licensed under a Creative Commons Attribution 4.0 International License.
