The Effect of Nucleotides, Autocoides and Neurotransmittors Upon Smooth Muscle of Blood Vesels and Lungs (In Situ and in Vitro)

Authors

  • Sead Brkić
  • Muzafer Mujić
  • Seid Huković
  • Husein Kulenović

DOI:

https://doi.org/10.5644/Radovi.158

Abstract

Acetylcholine, histamine and adenosine triphosphate induce increase of blood pressure in pulmonary artery and decrease in femoral artery of anesthetized dogs. Adrenaline and serotonin increased the pulmonal arterial blood pressure. The effect of ADP, and AMP was insignificant.

The relaxation and decrease of the response of isolated frog’s lung induced adrenaline, serotonin, AMP and adenosine. The spasm of the lungs smooth muscle was found after acetylcholine, histamine, ADP and ATP.

The comparison of the results got i n vitro with then in situ suggests conclusion that endogenic substances which induce relaxation of isolated lungs decrease the blood pressure in pulmonary artery. Direct effect of different active agents is rather important in regulation of respiratory movement.

References

Brkić S. et al.: Unpublished results, 1971.

Daly I. de B., and C. P. Luck: The effects of adrenaline and noradrenaline on pulmonary hemodynamics with spetial reference ’to the role of reflexes from carotid sinus baroreceptors. J. Physiol. London, 145: 108—124, 1959.

Elliakim M. and Aviado D. M.: Effect of nerve stimulation and drugs on the extrapulmonary portion of the pulmonary vein. J. Pharmacol. Exp. Ther., 133 : 304—312, 1961.

Furchgott F. Robert: The pharmacologv of vascular smooth musele. Physiol. Reviews, 7/2, 195—265, 1955.

Gaddum J. H. and H o 11 z: Localisation of the action of drugs on the pulmonary vessels of dogs and cats. J. Physiol. 77: 139—143, 1933.

Huković S., Igić R., Brkić S.: Reaction of the isolated lung to electrical stimulation of the associated nerves and to the physiologically active substances. Jugoslav. Physiol. Pharmacol. Acta, 2—3, 119—127, 1965.

Waller P. i Bassenge E. Effect of ATP, ciclic AMP, adenosine and Dipiridamole on isolated circular strip blood vessels. Pfliigers Arch. Ges. Physiol. 299/1: 52—65, 1968.

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Published

02.07.1972

Issue

Vol. 16 (1972): Radovi

Section

Works

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Copyright (c) 2026 Sead Brkić, Muzafer Mujić, Seid Huković, Husein Kulenović

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This work is licensed under a Creative Commons Attribution 4.0 International License.

How to Cite

The Effect of Nucleotides, Autocoides and Neurotransmittors Upon Smooth Muscle of Blood Vesels and Lungs (In Situ and in Vitro). (1972). Acta Medica Academica, 16, 119-125. https://doi.org/10.5644/Radovi.158

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