The Effect of the Heparin on the Development of the Histamin Shock and on Regencration of the Clotting Factors: Fibrinogen, Prothrombin (F II), Accelerin (F V), Konvertin-Stuart Complex (F VII—X) and Platelet During the Recovery After Shock

Abstract

While experimenting with the acute histamine shock caused by the histamine liberator Polymyxin-B, the authors studied the behaviour of some important clotting factors (fibrinogen, platelet, F II, V, VII—X) during the shock and a few hours period after shock. Increased and intensive consummation of fibrinogen, a slightly more moderate consummation of prothrombin and proaccelerin and partly of the complex konvertin-Stuart, and the decrease in platelet number during the first 15 minutes from the beginning of shock, suggests that the combination of various pathogenetic factors leads to the formation of the procoagulant conditions in blood, which would lead to the formation of microthrombi after the mobilization of the platelets. Heparin significantly prevents the development of the symptoms of shock and protects from the irreversible phase all animals to which it has been administrated. The appearance of the platelet the almost immediate platelet agglomeration in the beginning of the shock, when the fibrin cannot be observed among them even by electron-microscopy is still insufficiently clear. The role of that agglomeration, provided we know that heparin is not the protector of platelet agglutation although it checks the development of the shock and the consummation of all clotting factors, especially the prothrombin complex, neither is sufficiently clear. The authors think that these questions as well as the supposition that hepatocytes lesions contribute to the formation of the dynamics of the regeneration of clotting factors after shock, should be further investigated.