Ispitivanje fagocitarne aktivnosti retikuloendo-telijalnog sistema pomoću radioaktivnog zlata Au198 u pokusnom histaminskom šoku
DOI:
https://doi.org/10.5644/Radovi.231Abstract
Premda je od prvih spoznaja o funkciji retikuloendotelijalnog sistema (RES) prošlo više decenija (Aschoff, 1924; Kyono, 1920; Roulet, 1930; Rossle, 1939; Pasteur Vallery-Radot, 1957. i dr.), ona ni do danas do tancina nije poznata. U novije vrijeme se RE-sistemu pripisuje značajna uloga u patogenezi šoka te diseminirane intravaskularne koagulacije (DIC), kao i drugih slicnih stanja (Altura and Herschey, 1967, 1968; Gabrieli, 1968; Fine, 1959; Malm, 1966; Rittenbury, 1967; Zimmermann, 1969; Schildt, 1972; Zweifach, 1958. i dr.).
Veći broj radova o patogenezi histaminskog šoka (Nikulin i sar., 1959 — 1980), morfološke studije RES-a u stanjima šoka na humanom materijalu, te submikroskopska proučavanja ovog sistema u histaminskom šoku (Nikulin i sar., 1977, 1978 i 1979), podstakla su nas da funkcionalno ispitamo RES i njegovu fagocitarnu aktivnost u stanju eksperimentalnog histaminskog šoka, o čemu u literaturi nalazimo relativno malo podataka.
Cilj ovog rada je ispitivanje kinetike iščezavanja intravenozno unesenih elektronegativnih koloidalnih radioaktivno markiranih cestica zlata (Au198) iz krvi i njihovog zadržavanje u ćelijama koje pripadaju RES-u u jetri, slezeni i koštanoj srži kod eksperimentalnih životinja (kunića) u protrahiranom šoku izazvanom histamin-liberatorom (Polymyxin- B-sulfatom).
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