Non-interventional Pilot Study Evaluating the Efficacy and Safety of Lysozyme-based Therapy in Patients with Noninfectious Sore Throat

Selma Karakaš, Dženana Huduti, Meliha Mehić, Aziz Šukalo, Jasna Džananović Jaganjac, Amna Tanović Avdić, Amira Skopljak, Azra Dupovac, Zehra Sarajlić, Una Glamočlija


Objective. This study aimed to evaluate the efficacy and safety of lysozyme-based oral antiseptic in the therapy of non-infectious sore throat in teachers.

Materials and Methods. A non-interventional, prospective, pilot study was conducted with two examinations. The first was performed as part of a general medical examination. If a non-infectious sore throat was confirmed by clinical checkup and all other inclusion and non-exclusion criteria confirmed, patients were offered to be enrolled in the study. After signing the informed consent form, patients were advised to use lysozyme-based lozenges, six times a day, for a period of five days. A telephone call follow-up examination was performed within 24 hours from the therapy completion.

Results. This was a pilot study involving 25 adult patients of both genders. Lysozyme-based lozenges showed positive effects in relieving the symptoms of non-infectious sore throat in teachers. At the same time, the lozenges showed excellent tolerability, and no side effects were reported during the study. 92% of patients confirmed they would take the same medicine again due to the same problem. Conclusion. The results of this “proof-of-concept” study indicated that lysozyme-based antiseptic could be effective and safe in the treatment of non-infectious sore throat in teachers and should be further evaluated as treatment option in this condition.


Lysozyme; Functional; Dysphonia; Professional Exposure; Sore Throat

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