Peripheral nerve stimulation for treatment of postherpetic neuralgia: A Case report


  • Scott C. Palmer Department of Neurology (W.D.F., S.C.P., K.M.B.), Department of Critical Care (M.L.F.), Mayo Clinic, Jacksonville, FL
  • Alexis A. Jimenez Department of Pain Medicine Mayo Clinic Rochester, Minnesota


Postherpetic neuralgia, Peripheral nerve stimulation, Neuropathic pain


Neuromodulation techniques have been successfully used for a varietyof neuropathic pain conditions. Th e aim of this paper is to presenta case of the successful use of a subcutaneously placed peripheralnerve stimulator for treatment of intractable postherpetic neuralgia(PHN). A 57-year old man presented with a two-year history of leftthoracic pain that developed aft er a vesicular rash. Focal neuropathicpain had not responded to treatment with multiple analgesic medicationsand steroid injections. Th e patient had signifi cant relief followingimplantation of a peripheral nerve stimulator. Th is case represents acontribution to the small but growing body of evidence indicating thatperipheral nerve stimulation may be an eff ective option for treatmentof PHN not responsive to less invasive modalities.


Download data is not yet available.

Author Biographies

Scott C. Palmer, Department of Neurology (W.D.F., S.C.P., K.M.B.), Department of Critical Care (M.L.F.), Mayo Clinic, Jacksonville, FL

Alexis A. Jimenez, Department of Pain Medicine Mayo Clinic Rochester, Minnesota


MacDonald BK, Cockerell OC, Sander JWAS, Shoryon SD. Th e incidence and lifetime prevalence of neurological disorders in a prospective community-based study in the UK. Brain.


Benzon HT, Kiran C, Darnule A, Chung B, Wille O, Malik K. Th e prevention and management of postherpetic neuralgia with emphasis on interventional procedures. Regional Anesthesia and Pain Medicine. 2009;34(5)514-21.

Harke H, Gretenkort P, Ladleif H,. Koester P, Rahman S. Spinal cord stimulation in postherpetic neuralgia and in acute herpes zoster pain. Pain Med. 2002;94:694-700.

Johnson M, Burchiel K. Peripheral stimulation for treatment of trigeminal postherpetic neuralgia and trigeminal posttraumatic neuropathic pain: a pilot study. Neurosurgery. 2004;55:135-42.

Kouroukli I, Neofytos D, Panaretou V,Zompolas V, Papastergiou D, Sanidas G, et al. Peripheral subcutaneous stimulation for the treatment of intractable postherpetic neuralgia: two case reports and literature review. Pain Pract. 2009;9:225-9.

Yakovlev A, Peterson A. Peripheral nerve stimulation in treatment of intractable postherpetic neuralgia. Neuromodulation. 2007;10:373-5.

Bittar RG, Teddy PJ. Peripheral neuromodulation for pain. J Clin Neurosci. 2009;16:1259-61.

Melzack R, Wall PD. Pain Mechanisms: A new theory. Science. 1965;150:971-9.

Dorsi M J, Belzberg A J. Peripheral nerve stimulation. In: Fishman S, Ballantyne J, Rathmell J, editors. Bonica’s Management of Pain, 4th edition, Philadelphia: Wolters Kluwer/Lippincott Williams and Wilkins; 2010. p. 1375-8.

Cui JG, O’Connor WT, Ungerstedt U, Linderoth B, Meyerson BA. Spinal cord stimulation attenuates augmented dorsal horn release of excitatory amino acids in mononeuropathy via a GABAergic mechanism. Pain. 1997;73(1):87-95.

Slavin K. Peripheral nerve stimulation for neuropathic pain. Neurother. 2008;5:100-6.

Mobbs RJ, Nair S, Blum P. Peripheral nerve stimulation for the treatment of chronic pain. J Clin Neurosci. 2007;14:216-221.

Weiner RL. Occipital neurostimulation for treatment of intractable headache syndromes. Acta Neurochir–Suppl (Wien). 2007;97:129-33.

Paicius RM, Bernstein CA, Lempert-Cohen C. Peripheral nerve field stimulation for the treatment of chronic low back pain: preliminary results of long-term follow up: a case series. Neuromodulation. 2007;10:279-90.

Thimineur M, De Ridder D. C2 area neurostimulation: A surgical treatment for fi bromyalgia. Pain Med. 2007;8:639-46.

Meglio M, Cioni B, Prezioso A, Talamonti G. Spinal cord stimulation (SCS) in the treatment of postherpetic pain. Acta Neurochir Suppl (Wien). 1989;46:65-6.

Deer TR, Levy RM, Rosenfeld EL Prospective clinical study of a new implantable peripheral nerve stimulation device to treat chronic pain. Clin J Pain. 2010;26(5):359-72.

Nagy AM, Aeschbach A, Stanton-Hicks M. Cost benefit analysis of neurostimulation for chronic pain. Clin J Pain. 2004;20(6):462-8.




How to Cite

Palmer, S. C., & Jimenez, A. A. (2011). Peripheral nerve stimulation for treatment of postherpetic neuralgia: A Case report. Acta Medica Academica, 40(2), 187–191. Retrieved from



Case Report

Most read articles by the same author(s)