Pharmacological Analysis of Tremor Caused by Acetaldehyde
DOI:
https://doi.org/10.5644/Radovi.197Abstract
Acetaldehyde causes intentional tremor in mice. Pharmacological analysis has shown that this tremor can be abolished by the application of anticholinergic or antiserotonergic drugs. It is known that acetaldehyde increases the levels of 5-HT and noradrenaline in the brain. Noradrenalin can be responsible for the origin of some kinds of tremor, but our analysis has shown it does not alter the tremor caused by acetaldehyde. It is known whether acetylcholine is increased after acetaldehyde application or not. In our analysis it is shown that this component is of importance for the genesis of this kind of tremor since one inhibitor of cholinacetylase can remove acetaldehyde induced tremor.
The question is can parasympaticolytics and antiserotonergic drugs be of therapeutic value in tremor vvhich is present in chronic alcoholism. We do not know wether this antagonist of acetaldehyde induced tremor can be of some value in therapy of toxic symptoms that are present during application of acetaldehyde in the therapy of chronic alcoholism.
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