Application of Fluorescent Antibody-Test (FTA) in Syphilis

Authors

  • Ernest I. Grin
  • Mira Nadaždin

DOI:

https://doi.org/10.5644/Radovi.96

Abstract

The FTA at 1 : 200 dilution was tested and compared with complement fixation test, the VDRL and MKR on 244 patients in different stages of the syphilitic infection (not yet treated, in treatment, after treatment) on 17 problem, sera, 7 different skin disorders and 27 healthy children.

FTA test has proved to be highly sensitive, easily reproducible and specific.

In the ’untreated primary syphilis FTA was highly specific and slightly more sensible than standard serological tests.

In the treated patients the FTA persisted reactive for a longer time than any other classical serological test.

High specificity of the FTA test could be demonstrated especially in the group of latent syphilis and problem sera with biological false positive results.

References

Borel, L. J. i Durel, P.: Immuno-fluorescence applied to the diagnosis of syphilis. WHO/VDT/SERO/92, 1959.

Coons, A. H., Creech, H. J., Jones, R. N. i Berliner, E.: The demonstration of pneumococcal antigen in tissues by the use of fluorescent antibody. J. immunoil. 45, 159—'170, 1942.

Deacon, W. E., Falcone, V. H. i Harris, Ad.: A fluorescent test for treponemal antibodies. Proc. Soc. exp. biol. med. 96, 477—480, 1957.

Deacon, W. E., Freeman, E. M. i Harris, Ad.: Fluorescent trepo­nemal antibody test. Modification based on quantitation (FTA-200). Proc. Soc. exjp. biol. med. 103, 827—829, 1960.

Fife, H. E., Bryan, M. B., Sanders, W. R. i Muschel, H. L.: Evaluation of the fluorescent treponemal antibody (FTA) test for syphilis Comparison with Treponema pallidum immobilization (TPI) test. Am. J. clin. path. 36, 105—113, 1961.

Nielsen, H. A. i Idsoe, O.: Evaluation of the fluorescent treponemal antibody test (FTA). Acta path. et miorobiol. soandinav. 57, 331—347, 1963.

7. Wilkinson, A. E.: Fluorescent treponemal antibody test. A preliminary report. Brit. J. vener. Dis. 37, 59—63, 1961.

Published

26.09.1965

Issue

Section

Works

How to Cite

Application of Fluorescent Antibody-Test (FTA) in Syphilis. (1965). Acta Medica Academica, 11, 103-111. https://doi.org/10.5644/Radovi.96

Most read articles by the same author(s)

<< < 1 2