The Influence of Neuropharmaca on the Content of Choline in Brain
DOI:
https://doi.org/10.5644/Radovi.76Abstract
The influence of 33 drugs, from various pharmacological groups, on the content of choline in the mouse brain have been tested. The method we used gives the total amount of choline including one from acetylcholine. Results have showed that there is no correlation between the pharmacologic effect and the content of choline, when the drugs from similar or antagonistic pharmacologic groups were used. The influence of these compounds on the activity of cholinesterase or cholinacetylase was not in relation with the content of choline. Some drugs from the same pharmacologic group probable act differently the choline diffusion from central nervous system.
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