Fulminant hepatic failure in a neonate with systemic echovirus infection
Keywords:
Hepatic Failure, Neonate, EchovirusAbstract
We report the fatal case of neonatal fulminant hepatic failure due toEchovirus infection mimicking an acute metabolic decompensation.After exclusion of several metabolic disorders, the diagnosis of theinfectious etiology was confirmed by Polymerase Chain Reaction ofEchovirus in liver and spleen tissue. Establishment of etiological diagnosisand exclusion of inherited metabolic disease helped the familycounseling regarding risk for future pregnancies. Fulminant hepaticfailure in the neonate is a diagnostic and therapeutic challenge thatrequires a multidisciplinary management. Our case illustrates thebroad differential diagnosis, the common final pathway leading to severeliver injury, and the multidisciplinary approach to diagnosis andtreatment.Downloads
References
Schneider B. Neonatal Liver Failure. Curr Opin Pediatr. 1996;8:495-501.
Schafer DF, Shaw BW. Fulminant Hepatic Failure and Orthotopic Liver Transplantation. Semin Liver Dis. 1989;9(3):189-94.
Rand EB, Karpen SJ, Kelly S, Mack CL, Malatack JJ, Sokol RJ, Whitington PF. Treatment of neonatal hemochromatosis with exchange transfusion and intravenous immunoglobulin. J Pediatr. 2009;155(4):566-71.
Siafakas CG, Jonas MM, Perez-Atayde AR. Abnormal Bile Acid Metabolism and Neonatal Hemochromatosis: A Subset with Poor Prognosis. J Pediatr Gastroenterol Nutr. 1997;25(3):321-6.
Shneider BL, Setchell KD, Whitington PF, Neilson KA, Suchy FJ. Delta 4-3-oxosteroid 5 beta-reductase deficiency causing neonatal liver failure and hemochromatosis. J Pediatr. 1994;124:234-8.
Brusilow SW, Maestri NE. Urea Cycle Disorders: Diagnosis, Pathophysiology, and Therapy. Adv Pediatr. 1996;43:127-70.
Mazzella M, Cerone R, Bonacci W, Caruso U, Munnich A, Rustin P, et al. Severe Complex I Deficiency in a Case of Neonatal-Onset Lactic Acidosis and Fatal Liver Failure. Acta Paediatr.
;86(3):326-9.
Tóth T, Bókay J, Szönyi L, Nagy B, Papp Z. Detection of mtDNA Deletion in Pearson Syndrome by Two Independent PCR Assays from Guthrie Card. Clin Genet. 1998;53(3):210-3.
Bakker HD, Van den Bogert C, Scholte HR, Zwart R, Wijburg FA, Spelbrink JN. Fatal Neonatal Liver Failure and Depletion of Mitochondrial DNA in Three Children of One Family. J Inherit Metab Dis. 1996;19(2):112-4.
Shanmugam NP, Bansal S, Greenough A, Verma A, Dhawan A. Neonatal liver failure: aetiologies and management-state of the art. Eur J Pediatr. 2010; Epub ahead of print.
Mbida AD, Pozzetto B, Gaudin OG, Grattard F, Le Bihan JC, Akono Y, et al. A 44,000 Glycoprotein is Involved in the Attachment of Echovirus Onto Susceptible Cells. Virology Monographs. 1992;189(1):350-3.
Saudubray JM, Nassogne MC, de Lonlay P, Touati G. Clinical approach to inherited metabolic disorders in neonates: an overview. Semin Neonatol. 2002;7(1):3-15.
Pruekprasert P, Stout C , Patamasucon P. Neonatal Enterovirus Infection. J Assoc Acad Minor Phys. 1995;6(4):134-8.
Shafren DR, Dorahy DJ, Thorne RF, Kinoshita T, Barry RD, Burns GF. Antibody Binding to Individual Short Consensus Repeats of Decay-Accelerating Factor Enhances Enterovirus Cell Attachment and Infectivity. J Immunol. 1998;160(5):2318-23.
Wang J, Atchison RW, Walpusk J, Jaffe R. Echovirus hepatic failure in infancy: report of four cases with speculation on the pathogenesis. Pediatr Dev Pathol. 2001;4(5):454-60.
Gitlin N, Visveshwara N, Kassel SH, Byock IR, Rajani KB, Weinberg HM. Fulminant Neonatal Hepatic Necrosis Associated with Echovirus Type 11 Infection. West J Med. 1983;138(2):260-3.
Piraino FF, Sedmak G, Raab K. Echovirus 11 Infections of Newborns with Mortality During the 1979 Enterovirus Season in Milwaukee, Wisconsin. Public Health Rep. 1982;97(4):346-53.
Mostoufizadeh M, Lack EE, Gang DL, Perez-Atayde AR, Driscoll SG. Postmortem Manifestations of Echovirus 11 Sepsis in Five Newborn Infants. Hum Pathol. 1983;14(9):818-23.
Mertens T, Hager H, Eggers HJ. Epidemiology of an Outbreak in a Maternity Unit of Infections with an Antigenic Variant of Echovirus 11. J Med Virol. 1982;9(2):81-91.
Mulcahy DL, Hanlon MG, de Silva LM. A Report of a Spring-Summer Outbreak of Echovirus 11 Infection. J Infect. 1983;6:61-6.
Bose CL, Gooch 3rd WM, Sanders GO, Bucciarelli RL. Dissimilar Manifestations of Intrauterine Infection with Echovirus 11 in Premature Twins. Arch Pathol Lab Med. 1983;107(7):361-3.
Nagington J, Gandy G, Walker J, Gray JJ. Use of Normal Immunoglobulin in an Echovirus 11 Outbreak in a Special-Care Baby Unit. Lancet. 1983;2(8347):443-6.
Speer ME, Yawn DH. Fatal Hepatoadrenal Necrosis in the Neonate Associated with Echovirus Types 11 and 12 Presenting as a Surgical Emergency. J Pediatr Surg. 1984;19(5):591-3.
Gillam GL, Stokes KB, McLellan J, Smith AL. Fulminant Hepatic Failure with Intractable Ascites Due to an Echovirus 11 Infection Successfully Managed with a Peritoneo-Venous (LeVeen) Shunt. J Pediatr Gastroenterol Nutr. 1986;5:476-80.
Chuang E, Maller ES, Hoffman MA, Hodinka RL, Altschuler SM. Successful Treatment of Fulminant Echovirus 11 Infection in a Neonate by Orthotopic Liver Transplantation. J Pediatr Gastroenterol Nutr. 1993;17:211-4.
Chambon M, Delage C, Bailly JL, Gaulme J, Dechelotte P, Henquell C, et al. Fatal Hepatic Necrosis in a Neonate with Echovirus 20 Infection: Use of the Polymerase Chain Reaction to Detect Enterovirus in Liver Tissue. Clin Infect Dis. 1997;24(3):523-4.
Schwarer AP, Opat SS, Watson AM, Spelman D, Firkin F, Lee N. Disseminated Echovirus Infection after Allogeneic Bone Marrow Transplantation. Pathology. 1998;29(4):424-5.
Ward T, Powell RM, Evans DJ, Almond JW. Serum Albumin Inhibits Echovirus 7 Uncoating. J Gen Virol. 1999;80:283-90.
