Mogućosti upotrebe elektronske paramagnetne rezonancije u farmakološkim i toksikološkim ispitivanjima lijekova
DOI:
https://doi.org/10.5644/Radovi.262Abstract
Metoda elektronske paramagnetne rezonancije je spektroskopska metoda koja, između, ostalog, omogućava proučavanje različitih farmakoloških i toksikoloških osobina lijekova. Metodu je moguće koristiti za proučavanje resorpcije, raspodjele, eliminacije i metabolizma lijekova. Moguće ju je koristiti i za proučavanje efekata lijekova na receptore ili encime, odnosno na membrane ćelija i tkiva. Uticaji lijekova na membrane obično su rezultat različitih fizikalno-kemijskih osobina lijekova. Od naših istraživanja prikazani su rezultati s područja proučavanja acetilholinesteraze i holinoreceptora, kao i uticaja holinergičkih supstancija na fluidnost membrana.
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