Današnje gledanje na problem hroničnog hepatitisa
DOI:
https://doi.org/10.5644/Radovi.261Abstract
Na osnovu revijalne literature iznesena je definicija, proširenost, etiologija i klinička podjela hroničnih hepatitisa. Patogeneza i mehanizam razvoja bolesti su izneseni na primjeru uloge virusa hepatitisa B (VHB) u uslovima razvoja imunog odgovora organizma na ovaj virus kao antigen. Nedovoljan odgovor organizma je genetski predodređen i ta reakcija može biti rezultat snižene funkcije T-limfocita. Odlučujuću ulogu u razvoju hroničnog hepatitisa imaju različiti faktori, osobito u slučaju HBsAg pozitivnog i HBsAg negativnog oblika hepatitisa. Histološka i klinička karakteristika, kao i terapija, proističu iz poznavanja ovih imunih mehanizama, a konačna prognoza najčešće od rezultata ponovljenih biopsija jetre u ispitivanju provedenom ne manje od šest mjeseci. Konačno, proizvedeno je više vrsta vakcina protiv VHB koje imaju svoju budućnost u prevenciji i zaštiti ugroženih rizičnih grupa VHB.
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