The Disorders in Coagulation Status Under the Effects of Salicylate Treatment in Patients With Rheumatic Disease and Juvenile Rheumatoid Arthritis
DOI:
https://doi.org/10.5644/Radovi.216Abstract
Rheumatic disease and various mechanisms accompanying it have multiple effects on haemostatic factors; the treatment with salicylates multiplies these harmful effects. In the group of patients with rheumatic disease we established before, in the course, and after the treatment with salicylates the disorders of haemostatic factors: bleeding time, prothrombin time, aggregation of platelets and fibrinolysis. The effect was the bleeding tendency. Bleeding might be minimal or profuse.
The best method of treatment is substitution with haemostatic factors. In view of all these harmful effects, the treatment with salicylates in children treated with salicylates is the substitution with the factors which are and prophylaxis of bleeding. The concentration of salicylates in blood should not exceed 35 mg%, the values of blood sugar, acidobase status, electrolytes should be controlled.
The method of choice in the treatment of bleeding tendencies in children treated with salicylates is the substitution with the factors which are the most affected ones, i. e. platelets, fibrinogen and antifibrinolytic drugs.
References
Asker, A. F. et al. (1974): J. of Pharmec, Scienc. Accept. for publ .April 11, 1974.
Bošković, S. D., Mesihović, H., Sarajlić, E. i sarad. (1974): Naša iskustva sa blokatorima agregacije trombocita, II kongres hematologa i transfuziologa Jugoslavije, održan 29. V do 1. VI 1974. god.
Bowie, E. J. W. and Owen, Ch. A. (1969): Aspirin, platelets and bleeding, Circulation, vol. XI. 6:757.
Done, A. K. (1960): The nature of the antirheumatic action of salicylates, Clin. Pharmacol, Ther. I.: 141.
Drey fus, D. Le Lang (1971): Flammarion Medicine, Paris.
Ekheard, E. H., Reimold, M. D. et al. (1973): Salicilate intoxication, Am J. Dis. Child. vol. 125.
Gilchrist, G. S. (1972): Pediatr. Clinics of North America, vol. 19. No. 4.
Haslam, R. J. (1964): Nature, 202:765.
Heinrich, D. Schmutzler (1975): Med. Welt, 2174—2177, 26/Helt 48.
Hill, J. G. (1973): Effects of saltering blood Ph on salicilate distribution, Pediatrics 47:4.
Von Kaulia, K. N. (1970): Simpl test tubes arrangements for screening fibrinolytis activity of synthetic organic compouds, J. medicinal Chem. 8:164.
Kosorić, D., Sarajlić, E. i sarad. (1964): Vrijeme krvarenja, rezistencija kapilara i salicilati, Zbornik V pedijatrijskih dana BiH, Zenica.
Luscher, E. F. and Massini, P. (1973): On the Mechanism os the Induction oj the Platelet Release Reaction, Acta Univers. Saroline, Monogr. LIH—IV, 69—75.
Menon, S. I. (1970): Aspirin and blood fibrinolysis, Lancet i : 364.
Pinedo, H. M. (1973): LBA Ann. rheum. Dis 32, 66.
Sarajlić, E. (1973): Akutni salicilizam u djece, Radovi XLVIII. Odjelj. med. nauka, Knjiga 17.
Segar, W. E. (1971): Critically ill child: Salicilate intoxication, Pediatrics, 3:44.
Seegers, W. H. (1960): Chemistri of Protrombin and Trombin, IV internacional ni kongres biokemičara, Beč.
Silver, M. H., Bryan Smith and Sarol, M. (1974): Ingerman Agents and Actions, Birkhanser Vergal, Basel vol. 4/4.
Veltkamp, J. J. (1970): Aspirin and bleeders, The New Eng. J. of Med. 283, 435.
Zawilska, K. and V. Izreal (1973): Flaquetts et inflamations, Path. Biol. 21, 771—780.
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