Immunosuppressive-Free Renal Allograft Function After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report

Authors

  • Vedad Herenda Nephrology Clinic, Sarajevo University Clinical Center, Sarajevo, Bosna and Herzegovina
  • Vasvija Katica Hematology Clinic, Sarajevo University Clinical Center, Sarajevo, Bosna and Herzegovina
  • Lejla Burazerović Hematology Clinic, Sarajevo University Clinical Center, Sarajevo, Bosna and Herzegovina
  • Aida Hamzić-Mehmedbašić Nephrology Clinic, Sarajevo University Clinical Center, Sarajevo, Bosna and Herzegovina
  • Lejla Ibricevic-Balić Hematology Clinic, Sarajevo University Clinical Center, Sarajevo, Bosna and Herzegovina
  • Damir Rebić Nephrology Clinic, Sarajevo University Clinical Center, Sarajevo, Bosna and Herzegovina

DOI:

https://doi.org/10.5644/ama2006-124.469

Keywords:

Kidney Transplantation, Allogeneic Transplantation, Immunosuppression

Abstract

Objective. We describe a rare case of satisfactory renal allograft function without immunosuppressive therapy following alloge- neic hematopoietic stem cell transplantation (alloHSCT).

Case Report. The patient was a 64-year-old male who had undergone a kidney transplant from a sibling donor in 2007. After 16 years, he required alloHSCT for acute myeloid leukemia (AML), with the same sibling serving as the donor for both transplants. HLA was a 50% match. Post-alloHSCT, immunosuppressive therapy was discontinued, and the renal allograft function remained stable. The patient later developed severe complications and succumbed to infection. Insights into the precise tolerance mechanisms were limited because laboratory evaluation for chimerism was not performed.

Conclusion. There is potential for immunosuppressive-free renal allograft function after alloHSCT. This case underscores the significant risk of infection-related mortality. To achieve the best outcome, rigorous patient selection, tailored conditioning regimens, robust infection prevention strategies, and the possibility of combined transplantation for care- fully selected patients are needed.

Downloads

Download data is not yet available.

Downloads

Published

2025-03-26

How to Cite

Herenda, V., Katica, V., Burazerović, L., Hamzić-Mehmedbašić, A., Ibricevic-Balić, L., & Rebić, D. (2025). Immunosuppressive-Free Renal Allograft Function After Allogeneic Hematopoietic Stem Cell Transplantation: A Case Report. Acta Medica Academica. https://doi.org/10.5644/ama2006-124.469

Issue

Section

Clinical Medicine

Categories

Most read articles by the same author(s)

Similar Articles

1 2 > >> 

You may also start an advanced similarity search for this article.