Vitamin D-Binding Protein and the Role of its Gene Polymorphisms in the Mortality of Sepsis Patients

Authors

  • Liliriawati Ananta Kahar Department of Anesthesiology and Intensive Care, Faculty of Medicine, Andalas University, M. Djamil Hospital, Padang
  • Yusrawati Yusrawati Department of Obstetrics and Gynecology, Faculty of Medicine, Andalas University, Padang
  • Jamsari Jamsari Department of Biotechnology, Postgraduate Program, Andalas University, Padang
  • Tinni Maskoen Faculty of Medicine, Padjadjaran University, Bandung
  • Kornelis Aribowo Department of Pulmonology and Respiratory Medicine, Faculty of Medicine, Andalas University, Padang
  • Wiwi Monika Sari Intensive Care Unit, M. Djamil Hospital, Padang

DOI:

https://doi.org/10.5644/ama2006-124.428

Keywords:

Genetic Polymorphisms, Intensive Care Units, Sepsis, Vitamin D, Vitamin D-Binding Protein

Abstract

Objective. This study aimed to determine the role of vitamin D-binding protein (VDBP) gene polymorphisms (especially at locus rs7041), vitamin D-binding protein levels, and vitamin D levels in mortality in sepsis patients.

Patients and Methods. We performed the analytic observational study with a case-control approach. A total of 80 patients were included in this study, 40 patients were grouped as the case group and 40 patients were grouped as the control group. The patients were diagnosed with sepsis and treated in the Intensive Care Unit (ICU), M. Djamil Hospital, Indonesia. The VDBP rs7041 gene polymorphism was analyzed using the polymerase chain reaction procedure. VDBP and vitamin D levels were examined using the enzyme-linked immunosorbent assay (ELISA) method.

Results. The case group showed lower mean vitamin D and VDBP levels than the con- trol group (P<0.05). There were more variations in the rs7041 gene VDBP (mutant) locus in the case group than in the control group, and this difference was considered statistically significant, P<0.05. The results of this study indicate that the occurrence of polymorphism or variations at locus rs7401 (mutant) causes a decrease in VDBP and vitamin D levels. A decrease in vitamin D levels correlates with the incidence of mortality in sepsis patients.

Conclusion. Polymorphism gene VDBP at locus rs7041 causes a decrease in the production of VDBP, a vitamin D carrier protein.

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Published

2024-02-01

How to Cite

Kahar, L. A. ., Yusrawati, Y. ., Jamsari, J. ., Maskoen, T. ., Aribowo, K. ., & Sari, W. M. . (2024). Vitamin D-Binding Protein and the Role of its Gene Polymorphisms in the Mortality of Sepsis Patients. Acta Medica Academica. https://doi.org/10.5644/ama2006-124.428

Issue

Section

Clinical Medicine