A Comparison of Cathelicidin Levels in the Skin of Leprosy Patients and Their Household Contacts

Authors

  • Fifa Argentina Department of Dermatology and Venereology, Faculty of Medicine, Universitas Sriwijaya, Palembang
  • Oki Suwarsa Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung
  • Hendra Gunawan Department of Dermatology and Venereology, Faculty of Medicine, Universitas Padjadjaran/Hasan Sadikin General Hospital, Bandung
  • Afiat Berbudi Department of Biomedical Sciences, Parasitology Division, Faculty of Medicine, Universitas Padjadjaran, Bandung; Infectious Disease Research Center, Faculty of Medicine, Universitas Padjadjaran, Bandung

DOI:

https://doi.org/10.5644/ama2006-124.424

Keywords:

Antimicrobial Peptide, Cathelicidin, Enzyme-Linked Immunoabsorbent Assay, Leprosy, Neutrophils

Abstract

Objective. This study aimed to compare cathelicidin levels in the skin of leprae patients and leprae contacts.

Patients and Methods. This research is an analytic observational study with a cross-sectional approach. Fifty-four research subjects participated in this study. They consisted of leprae patients, household contacts, and healthy individuals. Cathelicidin levels were measured using the ELISA method. Data analysis was carried out with the help of SPSS software, and univariate and bivariate analysis was conducted.

Results. Cathelicidin levels in the leprae group (256.8±22.9 pg/ml) were higher than in the contact group (25.9±2.7 pg/ml). Likewise, the contact group had higher cathelicidin levels than healthy controls (1.4±0.1 pg/ml). Statistically, there were differences in cathelicidin levels between groups, P<0.050.

Conclusion. Cathelicidin levels in leprae patients were higher than those in household contacts.

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Published

2023-12-20

How to Cite

Argentina, F. ., Suwarsa, O. ., Gunawan, H. ., & Berbudi, A. . (2023). A Comparison of Cathelicidin Levels in the Skin of Leprosy Patients and Their Household Contacts. Acta Medica Academica. https://doi.org/10.5644/ama2006-124.424

Issue

Section

Clinical Medicine