Experiences with amine fluoride containing products in the management of dental hard tissues lesions focusing on Hungarian studies: A review

Melinda Madléna


Fluorides play a significant role in the promotion of oral health, fostering remineralization, inhibiting demineralization processes in the enamel, and having antibacterial activity. The effects of fluorides are mostly exerted by their topical effect. The beneficial effect of amine fluorides (AmF) on caries and dental plaque reduction has been known for a long time. The caries reducing and plaque-inhibiting effect of stannous fluoride (SnF2) was also reported. However, the combination of amine fluoride/stannous fluoride has shown a much better inhibition of plaque accumulation then these products alone. There have been several clinical studies with AmF or AmF/ SnF2 products, using toothpaste, gel, combination of toothpaste and gel/fluid, toothpaste and mouth rinse. The aim of this article is to review the clinical experiences with these products based on Hungarian studies. The first Hungarian studies with AmF containing gel were published by Szőke and Kozma (1989) and Dénes and Gábris (1991). Madléna et al. (2002) performed a study with an AmF-containing toothpaste and gel in high risk groups of adolescents. The first Hungarian study with AmF/SnF2 products was published by Bánóczy et al. (1989). Based on the favourable results of these products used in combination for 12 weeks, other studies (Madléna et al. 2004, 2012) assessed the effects of toothpastes and mouth rinse containing AmF/SnF2 on plaque accumulation, within a shorter period of time, in young adults and orthodontic patients. Conclusion. Regular use of different oral hygienic products containing an AmF and AmF/SnF2 combination contributes to the prevention of plaque accumulation and consequently to the prevention of dental diseases.


Amine fluoride; Amine fluoride/Stannous fluoride; Plaque accumulation; Prevention; Oral health

Full Text:


DOI: http://dx.doi.org/10.5644/ama2006-124.86


  • There are currently no refbacks.

2019 Department of Medical Sciences, Academy of Sciences and Arts of Bosnia and Herzegovina, Sarajevo, Bosnia and Herzegovina. All rights reserved.
The full text of articles published in this journal can be used free of charge for personal and educational purposes while respecting authors and publishers’ copyrights. For commercial purposes no part of this journal may be reproduced without the written permission of the publisher.