Respiratory Virus Infections in Asthma: Research Developments and Therapeutic Advances

Authors

  • Kartik Kumar National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, Department of Respiratory Medicine, St Mary’s Hospital, Imperial College Healthcare NHS Trust, Praed Street, London, W2 1NY
  • Aran Singanayagam National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, Department of Respiratory Medicine, Harefield Hospital, Royal Brompton & Harefield NHS Foundation Trust, Hill End Road, Harefield, UB9 6JH
  • Sebastian L. Johnston National Heart and Lung Institute, Imperial College London, Norfolk Place, London, W2 1PG, Department of Respiratory Medicine, St Mary’s Hospital, Imperial College Healthcare NHS Trust, Praed Street, London, W2 1NY, MRC and Asthma UK Centre in Allergic Mechanisms of Asthma, Imperial College London, Norfolk Place, London, W2 1PG

DOI:

https://doi.org/10.5644/ama2006-124.292

Keywords:

Asthma, Respiratory Viruses, Interferon, Therapy

Abstract

Abstract In this review, we discuss the latest developments in research pertaining to virus-induced asthma exacerbations and consider recent advances in treatment options. Asthma is a chronic disease of the airways that continues to impose a substantial clinical burden worldwide. Asthma exacerbations, characterised by an acute deterioration in respiratory symptoms and airflow ob- struction, are associated with significant morbidity and mortality. These episodes are most commonly triggered by respiratory virus infections. The mechanisms underlying the pathogenesis of virus-induced exacerbations have been the focus of extensive biomedical research. Developing a robust understanding of the interplay between respiratory viruses and the host immune response will be critical for developing more efficacious, targeted therapies for exacerbations.

Conclusion. There has been sig- nificant recent progress in our understanding of the mechanisms underlying virus-induced airway inflammation in asthma and these advances will underpin the development of future clinical therapies.

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Published

2020-11-11

How to Cite

Kumar, K., Singanayagam, A., & Johnston, S. L. (2020). Respiratory Virus Infections in Asthma: Research Developments and Therapeutic Advances. Acta Medica Academica, 49(2), 130–143. https://doi.org/10.5644/ama2006-124.292

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