The relationship of Bradykinin B2 receptor gene variation with obesity, hypertension and lipid variables in obese patients

Authors

  • Nur Bakir Marmara University, Faculty of Science and Arts, Department of Biology Istanbul
  • Hasan Mert Bozkus Marmara University, Faculty of Science and Arts, Department of Biology Istanbul
  • Meliha Koldemir Gündüz Marmara University, Faculty of Science and Arts, Department of Biology Istanbu
  • Penbe Çagatay Istanbul University Istanbul Medical Faculty, Department of Biostatistic and Medical Informatics, Istanbul,
  • Mustafa Taskın 3Istanbul University Cerrahpasa Medical Faculty, Department of General Surgery Istanbul
  • Belgin Süsleyici Duman Marmara University, Faculty of Science and Arts, Department of Biology Istanbul

DOI:

https://doi.org/10.5644/ama2006-124.113

Keywords:

B2R C-58T polymorphsm, PCR, Obesty, Serum lpds, Oral antdabetc

Abstract

Objective. This study examined the association of C-58T genotypes with obesity/hypertension related parameters and serum lipids in obese (n=108) and non-obese (n=80) patients. Materials and methods. Bradykinin receptor (B2R) C-58T genotypes were determined by PCR–RFLP. Results. B2R gene C-58T frequencies for T/T (homozygous wild type), T/C (heterozygous) and C/C (homozygous polymorphic) genotypes for obese and non-obese patients were respectively: 36.1%, 37.5%; 45.4%, 52.5% and 18.5%, 10%. Obese patients using diuretic medication had lower C/C genotype frequency compared to T/T and T/C genotypes. Total cholesterol (T-Chol) (p=0.035) levels were found to be associated with B2R C-58T polymorphism, where the T/T genotype had higher total cholesterol levels compared to the T/C genotype in obese patients. Non-obese patients using oral antidiabetic medication had higher C/C genotype frequency than that of T/T and T/C genotypes. Waist circumference (p=0.016) and diastolic blood pressure (p=0.01) levels were elevated in the non-obese subjects with the C/C genotype compared to T/C and T/T. Conclusion. Although B2R C-58T gene polymorphism was not found to be effective on obesity with logistic regression analysis in the whole study population in obese subjects, the T-Chol decreasing effect of the B2R gene C allele and the higher waist circumference measurements in the non-obese subjects may indicate there may be a link between B2R gene C-58T polymorphism and obesity in study populations of higher numbers.

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Published

2014-12-08

How to Cite

Bakir, N., Bozkus, H. M., Gündüz, M. K., Çagatay, P., Taskın, M., & Duman, B. S. (2014). The relationship of Bradykinin B2 receptor gene variation with obesity, hypertension and lipid variables in obese patients. Acta Medica Academica, 43(2), 144. https://doi.org/10.5644/ama2006-124.113

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Original Article